A Wizard with Mana Leak can cast both BICEPS and LEMMISI for free. (Even while mana burned.) A Wizard with Mana Leak and both BLUDTOPOWA and HALPMEH can regenerate
60 HP per tile - and can do so
using LEMMISI because LEMMISI is, again,
free. (And, of course, BICEPS for a permanent +30% damage boost
and pierce resists.) You might think this is excessive use of italics, but I assure you it is not. If anything, it is insufficient use of italics. If I had the time and energy to actually go through with a limited unlock profile I would go beat all the vicious dungeons Purist, but I don't, so just assume that I did and fix it already.
Another, more subtle change - Warlords get the pierce resist bonus from quaffing mana potions, since their class ability is literally the same thing as the BICEPS "Might" effect. That's kind of a buff to Warlords, I suppose, but it's also kind of a wash because Warlords don't benefit as much from 1 MP BICEPS because it doesn't stack with the potion effect.
I'll also note that I'm a tiny bit annoyed at Mystera's on worship effect being apparently piety based on spells already cast - that means optimal play now means spamming glyphs
all the time while you explore just in case you find her altar, otherwise you're wasting tiles that could become piety.