My previous laptop always crashed when Unity had fully loaded the game (black bar at the beginning of the game was full, then crashed). Nowadays with a much newer laptop, I never have Desktop Dungeons crashed once.
So I assume it has to do something with one or more aspects about the hardware:
Older laptop had 2 GB DDR2 RAM, new laptop 4 GB DDR3 RAM (so too little RAM may be an issue)
Older laptop had an integrated Intel GMA X3100 card with 144 MB VRAM, new laptop a dedicated ATI Radeon HD 6750M card with 512 MB VRAM (so too little VRAM may be an issue)
Older laptop had a 2.1 GHz Core 2 Duo cpu, new laptop has a 2.2 GHz Sandy Bridge i7 cpu, though I don't think it has something to do with this.
Older laptop used Firefox or Aurora
, newer laptop uses Chrome, though I don't think it has to do something with this.
Decrease your RAM by putting less RAM in your pc or running an application or virtual machine eating your precious RAM and some CPU power. Or buy a cheap netbook running Desktop Dungeons inside the browser, looking for crashes. -- just for testing purposes of course.