The altar situation makes certain strategies difficult if not impossible - Binlor, JJ, Earthmother, and GG are all basically useless except perhaps for last ditch refreshment - but other strategies are almost completely unaffected. Mystera in particular, since as long as you spam glyphs on the surface she'll give you 100 starting piety, enough to buy a good number of her boons. Taurog, too, if his boons were actually worth taking in that dungeon. Tikki Tooki can also work pretty well, seeing how much gold you end up with. Really, the whole altar situation in Naga City feels rather clunky, it shuts down some things but not others, and illustrates how poorly some of the deities do if you don't get access to them until very late (Binlor and JJ in particular, since getting enough piety to make effective use of them is nearly impossible).