How about the flavor for Mystic balance said it only applied to non-hermfull glyphs? PISSORF wouldn't mind (and the wizard wouldn't be as gimped), and fireball users would be restricted to picking up flames if they want to get fireballey.
Just a note, unless crystall ball gets a serious nerf, flames is actually a good boon. You can get really, REALLY silly with bloodmages (I actually rffectively fireball spammed naga city to death with no gods but mysterea and practicaly miser).
As for APHEELSICK - I'm not completely sure you're not overreacting. You ARE right about it being rather useless in the early game, and it does cut the assasin off from what is my favourite tactic as well, but the old effect was factually broken, and so was the assasin. All the time. People were converting old APHEELSICK on start the way it was, and right now, I'm pretty sure I wouldn't convert it on sight for:
wizards, assasins, monks, rogues, berserkers, tinkers, fighters, sorcerers... practicaly anything that melles. Sure, it costs a bit less than a fireball, but at some point it still means you get to stack it every five steps to shut down a monsters regeneration - which still allows you to break a fundamental rule of the game. It's better on regen fighters (and silly on monks), but it's a blackspace fueled glyph - small wonder. Honestly, the only thing any class but the berserker needs to beat any dungeon with mana based damage right now (or so I suspect) is prepping crystal ball and/or running into B2P, and you might prep mysterea for extra sillyness.
B2P is insane at any point of the game, but is in fact useless to (edit) non-spellcasters - I don't mind apheelsick only being usefull to melee guys.
Am I wrong somewhere?