This might be old news to at least some people, but I just found it out and it's hlarious.
You know how every vet at some point finds a silly way to make a better shortcut in the Matron subdungeon? Slayer Wand, Wheytwut, Lemisi, B2P, Endiswall, all that? I found the mother of all just now!
Wonnafyt. Get to lvl 10, make sure you prepped a Slayer Wand. Slayer wand one guy, stand in the middle and cast wonnafyt. Matron is lvl 10, she comes to fight, and that's it. Works with any class.
Inb4 nerf