Yesterday I was in Naga City with a Sorc and found a BludToPowa and MAN did I wreck that place.
I never noticed the synergy of Essence Transit (get 2 health per mana point spent) and BludToPowa (get 3 mana per 3*level health spent). You can just tick tock between fireballing and BludToPowa and easily kill a lvl 9 enemy at lvl 5 in a heroic dungeon oO
You could even get to lvl 2 and use a Fireball-B2P-B2P routine to get down the boss. As long as you have blackspace you can do that oO Combine that with a Dragon Soul or Mystera Fire and Mystic Balance or EM corrosion + clearance (oO^^) and and and.
I am not sure if it is possible to kill a boss on lvl 1 with this because its a bit scummy (you need B2P and prep:fireball) but its really awesome^^