Hmm... this is a difficult question to answer without having a good idea of your skill. You say you have a good sum of dungeons unlocked as well as all of the gods, so I can imagine you're tackling the hard dungeons. Are there specific dungeons you're having trouble with? Some are definitely harder than others, and some favor certain approaches and playstyles over others.
In any case, some generic advice:
-I'm sure you at least have a good idea of this by now, but still, it bears repeating: Only fight higher-level monsters when possible. If it's not possible, try very hard to find a way to make it possible
Experience is arguably the most important resource in the game. Keep low-level monsters around to use as mid-fight level ups, especially against the boss(es) - getting used to that skill alone can carry you through most normal and hard dungeons.
-Familiarize yourself with the Gods! Seriously, there's very little that can improve your playing more than a good understanding of every deity. Which gods favour which playstyles? Which are good to worship early, which ones might you wait before worshiping? When and to whom should you convert between deities? How do the different boons interact? If the deities scare you (and that's totally understandable!), I recommend going into Hobbler's hold (the easy dungeon) and just messing around with the Gods, since there's so little to lose. Fill out the likes/dislikes section of the codex, figure out what their punishment is, and so on, so that you can have access to that information on hand.
-The concept of blackspace conservation has multiple levels of complexity. First-time players often waste loads of blackspace without thinking much about it and end up short; they eventually realize how important it is to keep at as a resource and learn to treat it carefully. HOWEVER: it is easy to forget, after initially having learned this, that the *knowledge* that exploration gives you (where are my glyphs, altars, who's the boss in the dungeon, what subdungeon, shop items) is also an important "resource"! So "wasting" blackspace early on to get a feel for what is in the dungeon and acquiring tools necessary to the level up process can end up saving you loads of resources in the long run. Then of course you have to get a good feel for how different classes use (and need) blackspace differently (most obvious example being the Monk, but each class has its subtleties), but that comes later and with time.
-Also: Regen-fighting. It's really tough to learn (at least it was for me), but I do recommend having a look at the annotated playthrough that shows it off. Learning to incorporate this tactic in your play can make a huge difference, but this is also one of the last things I learned about this game, so I'll leave it up to someone else to go into more detail if they feel like it. However, do keep in mind the regeneration rates of enemies and yourself at all times; sometimes, you'll see that regenerating one square or two will be just enough to kill the enemy, even if you normally couldn't out-regenerate them. This is a useful skill and a good "intro" of sorts to regen-fighting in general.
-Beginners are often told to hoard all potions until the boss(es) (this is typically to keep them from wasting them pointlessly). However, if you want to get a good feel for all of the other resources in the game (including what I've outlined above), try and go one further - Try to complete the dungeons without any potions! This will force you to learn to use other resources you might overlook because you can finish things off well enough with potions. Start this off with the easier dungeons, the ones you're familiar with, of course. (As a note: Veterans of the game don't always agree on when non-boss potion use is appropriate/optimal).
Hopefully this helps; let me know if it doesn't, or if you'd like more specific advice! in the meantime, I'm sure other posters will come and give better advice