Another general tip that I'm sure most reading this are aware of: It's really important to preserve popcorn up top. You're going to need 3 for the curse floor, 3 for the curse scroll (assuming you want it, which you probably do), and probably 4ish for the curse dragon. Then you'll want a few to efficiently deal with the dancing blades, and another one or two for late game blood swells is a good insurance policy.
All of that because max resists are almost essential for the last room or so + Horatio. I have won with the just DS + Drac + curse scroll (38%) but I had GETINDARE and bought platemail for H.