The change to Quicksilver Potions should make them actually useful now (much less useful for Rogues and probably also Assassins than for other classes, since it's harder for them to game, but still a good item all around). I think the Fire Heart is probably just about perfect, too. And I am very happy with the new locker reclamation - it's especially nice for Sensation Stones. Now I feel like the Insurance prep should give you +100 gold for every item lost, allowing the player to commit insurance fraud.
I tried out the new Treasure Chest preparation, but one of the chests gave me a blank dialogue box. I think it might have reduced by HP to 1?
From what I can tell, these are the new deity punishments:
Mystera +15% phys & magic resist to all enemies
Tikki Tooki first strike & weakening added to all enemies
Taurog -40% attack bonus
Dracul -20 max HP (still no effect at 1 max HP)
Binlor reduces player's phys & mag resist by 50% (doesn't seem to affect maximums)
Glowing Guardian removes all items, including locker items
Mystera joins GG as a deity who you should now never, ever piss off 99% of the time regardless of your strategy. Tikki Tooki is also a lot harsher, but his penalty can still be mostly ignored by spellcasters. Binlor goes from having a nasty punishment to having one that you can shrug off with 10/13 classes as long as you're careful about when you desecrate. Dracul is harsher at lower levels but still subject to abuse by spellcasters and CYDSTEPPers. Taurog is slightly less harsh than before, but subject to the same rule: spellcasters can ignore it, fighters should avoid except in very rare circumstances.