I have the same problem that was posted in this thread on the Steam forums:http://steamcommunity.com/app/226620/di ... 179493357/
I have ESET Smart Security and I have tried disabling it and whitelisting the Desktop Dungeons directory (heck, I tried my entire Steam directory).
The thing I have discovered is as long as it doesn't try loading a saved game it works. Right now, if I try to start the game I get the error in the topic title. If I delete the save folder it will load and I can play. Restore the save folder and it will crash again. Please help.