In some cases the Transmuter is badly broken.
Expending all ressources i was able to get around 420 damage at lvl1. Killing ONLY the three bosses in Magma Mines is also possible (prepping Tikki Tooki and one need only a little scumming for WEYTWUT).
For both see: viewtopic.php?f=3&t=2409&start=40
I also tried the Dragon Isle, but the Frist Born with more than 600hp was a little bit to much. Later i realised there is a far better approach, which should work everywhere. Buffing till one can one-shot a lvl9 (ressoures needed: most of the exploration tiles + 1-2 glyphs) worshipping Tikki Tooki and the boss should be easy. Two layer dungeons with black tiles give also a second buff for the final battle.
Why is this approach broken:
1) LEMMISI is the only glyph which is totaly spamable. With orc one gets only from the glyph around 5 conversion (didn't count, but in the end i had 15: all the glyph and some conversions from items).
2) The ability itself: Upon conversion one gets 5+mana damage. Even without mana this is a boost of 5 damage / 7 in case of orc
Possible ideas to fix this:
1) Exclude LEMMISI from the ability. Or make it so that the glyph needs a minimum mana cost.
2) Change the ability from 5+mana damage boost to mana damage boost.