Don't know if this is known or not, but probably not everyone has figured it out, or it isn't even intended.
Reflex Potions give you two attack, one before and one after the most, if you aren't slowed or the monster has first strike.
There are some temporary boosters, which give a bonus to attack (all the Might stuff) or to damage (Strength potion) for one attack.
If one combines these two, the bonuses are applied to both attacks, not only the first
This gives a nice damage boost.