Glowing Guardian
-Powerful and versatile for most classes, gives benefits at all stages of the game.
-Constant easy piety gain, some restraints on glyphs, potions and non-sanctified butchery.
-Little variation in boon strategy, Absolution and cleansing are seldom used, constantly sanctifying is essential but laborious.
-Reasonable to switch to or from another god.
-Harsh desecration penalty, especially if magic-focused.
Taurog
-Powerful for melee-focused classes against enemies without heavy physical resist, gives benefits at all stages of the game.
-Constant easy piety gain, heavy restraints on glyphs and inventory space.
-Little variety in boon strategy, all roads lead to Unstoppable Fury.
-Not great for god-switching, as Taurog rewards dedication.
-Weak desecration penalty, none if switching to magic damage.
Mystera Annur
-Powerful option for magic-users in general, especially those with sidestep or heal, gives benefits at all stages of the game.
-Piety gain increases with mana pool, some restraints on enemy types and conversion.
-Some variety in boon strategy, though largely focused on the Magic boon.
-Reasonable to switch to or from another god.
-Weak desecration penalty, none if switching to physical damage.
Tikki Tooki
-Good options for early to mid-game, lacks good boon for late game.
-Piety gain increases over time, some restraints on sustained combat.
-Some variety in boon strategy, though Quicksilver and Reflexes are weak. Reflexes appears to only work if you strike first. Quicksilver has poor synergy with Dodge, as there's over a 29% chance you would've dodged anyway when it triggers... over 61% if you're a rogue with Dodge.
-Excellent candidate to switch from, weak to switch to, as his best benefits are long-term.
-Medium desecration penalty, none if switching to magic damage.
Dracul
-Very good options for boss fights, few benefits early game.
-Piety gain is mainly tied to reducing max health, some restraints on enemy types, glyphs and potions.
-Some variety in boon strategy, though Blood Hunger and Blood Shield are weak in boss fights, Dracul's apparent focus.
-Excellent candidate to switch to, weak to switch from. He's at his best full healing you in a boss fight until you get below 1-hit range, then trading max health for max mana.
-Harsh desecration penalty, none if switching to magic.
Comment Section
On Dracul - Is a bossfight switch to Dracul, Blood Swelling as long as you can, then Blood Powering until you can't his intended purpose? His boons have variety but base piety gain is so slow, and there's so many undead enemies, that you can literally--literally--get to 25 piety faster by starting as a different god and switching to him.
On Tikki Tooki - Tikki has the opposite problem of Dracul, though that makes them a good pairing. After Tikki's Edge and Dodge, there's no real reason to stay with Tikki; Tikki's Edge is much worse on the second go-around than the first, the two potions are useless, and Poison is best with repeated hits, which Tikki dislikes-but other gods are fine with, if you switch after obtaining it.
For the curious, the 29.6% with Reflexes is .1+.8(.1+.7(.1+.6(.1+.5(.1+.4(.1+.3(.1+.2(.1+.1(.1)))))))). 10% that you would've dodged anyway on the first hit, 8% on the next (because there's only an 80% chance that you didn't dodge on the first hit), 5.6% on the third (70% chance out of the 80% that you didn't dodge yet) and so on.