Another easy one (tested today) is to start with the Taurogzerker and then switch to Glowing Guardian underground.
I went for Orc, Dragon Shield, Patches, Fewer Glyphs, Transloc, fancy potions and Taurog. In retrospect, Compression is probably the better seal and Viper Ward would be my item of choice if I didn't have Dragon Shield.
Basically play the overground as your regular Taurogzerker, convert all glyphs if you like, though if you're not as confident or fussed about badges then keep one of Halpme, Lemissi or Getindare if you find it. Pray for Taurog's items, pick up the sword but don't rush for the others unless you're already done with buying stuff up and converting it. Grab a death protection. Anyway, don't worry if you can't clear the overground without chugging potions or taking corrosion, get near to a level-up and then head downstairs. You'll probably have around 100 damage or more, a goodish number of hit points and 65% MR and 15-30% PR.
Downstairs regen fight to take out a wussy boss like Aequitas or flatten Tomithy or someone like that with reflex, Quicksilver and strength potions (Curse is not good, clear it immediately with popcorn). After you've knocked out one you can unlock Golden Guardian, convert and use Cleansing and Whupaz to flatten Goo, you can probably just regen fight TS and if you finish a wave poisoned Cleansing can clear that. Most bosses you can regen fight to death happily. Feel free to convert Taurog's Helm, as an orc it's not a big net loss in attack power in exchange for the extra bead-space or using Yendor or something. I recommend the pact that gives you overheal on level up, since you'll get a couple anyway and you can Yendor for another. Throw in protections and/or healing potions (desecrate Earthmother for piety and indulgences if you have to) and you should win comfortably. Alternatively you could play it like the old-school Naga City and do a consensus-swap to Dracul for blood swells once the poisoners and physical resistance enemies are down.
My favourite sneaky combo synergy trick in this is that once you hit level 10 as a berserker you lose your +20% attack bonus vs higher level enemies BUT with Golden Guardian you can use humility to drop back to level 9 and keep it against the bosses. Which is the only specific use for high-level humility I've found yet.
I got Warmonger and Feeling Parched with ten or fifteen tiles to spare and no conversion into Drac, if you keep a glyph or use indulgence-based healing potions there's a huge margin for error here.