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Boss: Firstborn, Matron of Flame
Defeating the Firstborn will unlock the path to the Lair.
The Lair is a narrow corridor that starts with two Dragon Guards flanking a wall that vanishes if they're defeated, followed by four Dragon Elites and finally the Matron of Flame.
After the interminable curse-corrosion-weaken trifectas of most Vicious dungeons, this is a fresh breath of air. Prefer HALPMEH to PISORF or BURNDAYRAZ, as there are no walls and the Matron retaliates.
Assassin - Play competently enough to reach level 10 in the main dungeon (A Balanced Dagger or the Goblin race may be useful); this will allow you to make short work of the Matron's escort and handle her as you would handle a slightly lighter-weight Super Meat Man.