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PISORF is the knockback glyph, and it will send the target monster flying back one square, dealing damage to it if that square is not empty.
Unlocking the glyph
The PISORF glyph begins unlocked
A free PISORF glyph is awarded when worshipping Binlor Ironshield. Converting to Binlor's religion will not grant you the glyph.
The damage dealt by PISORF is proportional to your base attack, which means that the Orc race is especially competent with it. It has a low mana cost, and proportionally gains a huge advantage from the Wizard spell cost discount. This makes Orc Wizards shockingly effective PISORF casters. For everyone else, it's a useful way to deal physical damage without having to suffer retaliation from monsters.
The PISORF glyph is the only glyph in the game that will bypass a monster's magic resistance, allowing you to use it against bosses such as the Iron Man who are otherwise impervious to magic. Because it deals physical-type damage, it can allow you to very easily obtain the Specialist badge.
Additionally, PISORF does not trigger Retaliate: Fireball or Blink, making it very useful against late-game monsters like Djinns and Shades.