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The snake is a poisonous monster, and is one of the more common foes in the world of Desktop Dungeons. Aside from its poisonous bite, the snake is otherwise a mediocre monster with no special properties. Anyone who focuses on spellcasting to bring them down or who has the HALPMEH glyph to cure poison will find snakes to be an easy form of XP. If you do not have a method to cure poison, you should fight and slay snakes just before leveling up, or else try to kill them without suffering attacks. Having to use a healing potion just to cure poison is a waste of a potion in most cases and you should avoid having to do so if at all possible.
The Snake boss is literally just an oversized snake. He has no additional special abilities other than improved attack damage and health that all bosses receive. This makes him one of the easiest bosses in the game.