
I thought it would rock socks with the Monk, who naturally benefits from poison-like effects, but the thing is that attacking very high level monsters with melee is too expensive. Fireballers can safely start in on whatever target they want without having to worry about monster damage.
I didn't know about the Whupaz-Zot interaction. I just tried it and it works as advertised. Wow. That's really powerful. It knocks the boss down to 3/8 health in one shot. It's probably best not to do it right away, but rather use Zot effect to kill mid-level monsters until you're strong enough to finish the boss in one pass. Otherwise, the boss heals back to 1/2 and you lose some of the power of the combo. I used an elf sorcerer and was able to kill a Wraith-5 at first level, which made it possible to finish the boss with a whupaz-quicksilver-ding combo.