I use Chrome with only adblocker installed.
With I try IE, Unity just crashes all together.
Whenever I play the game and do something else/switch to other windows, the game often just locks out with a grey screen as well and doesn't respond anymore after that. Then when I try to reconnect I often can not because the Unity loading bar is stuck at 100%. (Seems to automatically fix itself after a "while")
All of this kinda ruins the "lets go for a quick game" which roguelike games are all about imo.