What i've already done:
VHoS:
Orc Berzerker (with dragon shield i think)
Elf Sorcerer (elven boots + fireball + found JJ)
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Would think a Wizard could work similar to the Sorcerer (less mana but spells are cheaper; Sorcerer destroys the DP faster, but i think with the Wizard it should also work). Probably Dragon Soul instead of Elven Boots and don't care about resistence (advantage: no fear of curses).
Other ideas? Please nothing which worships Mystera, think for me she would be suicide in this dungeon, since the easy monsters all have magical attacks

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NC:
Did it with an dedicated Orc Rogue once:
Dragon Shield + prepped TT. First high level kills -> join TT -> farm piety -> stack poison. In underground i converted to Dracul for Lifesteal.
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With an assassin a similar strat could work. But for other classes i don't think so.
PISSORF Orc Wizard sounds like a nice idea...