Oh? Well, you can still spike like a mad person, in theory. Depending on the threshold, it's a crazy ass CP bonus.
And debuffs are either incredibly crippling or a complete non-issue as long as soul orb, viper ward and halpmeh do what they do, for those that want to scumm/prep them.
EDIT: Also, if you are spiking the boss and don't mean to explore while you are at it, full heal pretty much = poison removal unless poison prevents it. Mana burn is trickier, but as long as you chug a single potion, then you can proceede with the spike. But all this is educated guesses, it all might turn out completely different because there's no way to tell how the other abilities will affect the gameplay without trying it out
