
For example I've recently been toying around with the Elf Rogue. On paper it looks really silly. Though pack on it a deity like Mystera, and it's quite decent (not top notch, but can be close). The idea is to ignore health, and go for a standard 3x-4x fireball + first strike melee finisher hit. Most foes who are problematic for one of these attacks are usually susceptible to the other. Foes who have lots of health usually have low damage, so the character can even take a hit from them. Definitely different from a machine like the Orc Rogue.
The other combination I catch myself playing is the Halfling Tinker. Yes I know Tinkers are better with permanent bonus races like Human, but still, it's kind of my fall-back guy if I don't have any good ideas what to play. Potions are pretty cool get-out-of-jail free cards, they can facilitate higher level kills, power shennanigans (TM Lujo), and anything left for the end game can be used to grease the bossfight. And all Tinkers are, well, pretty cool (nuff said

Lastly, I've had some decent success lately with the Orc Thief of GG. I normally play Thieves as Gnomes or Halflings, but it's an interesting fact that a Thief does the same amount of damage on the first hit as the Rogue, and although it lacks the other benefits of the Rogue like First Strike and Dodge (two super-powerful traits), it does have more health, more mana, more of everything basically. In a sense, in the average fight, being able to tank one additional hit is comparable to having first strike. Thief relies more on glyphs but luckily he also has more of that. GG is just a low-profile deity, good for a piety farm, nice to boost health/mana further if desired, and the +5 damage / +14 health from Humility also helps; optionally can be left later on for someone who doesn't mind opportunistic potion quaffs.
And very lastly, there's the Goat of Dracul. Since we established that Goats are peaceful (read: violently psychopathic), vegans (read: blood-thirsty cannibals), what deity goes better with them than Dracul? Dracul is surprisingly lenient once a few rules are obeyed, and the rules can still be broken when he is not watching... Plus, he offers the decent combination of not needing a glyph to interact with him; granting some boons that can be picked up already on low level; not losing out on half the fun when he's not watching; and having a non-prohibitive set of pet peeves.
Others?