I just picked up Desktop Dungeons at the end of January 2011, and I'm loving it. I've never played a roguelike before, but this game has inspired me to seek out other examples of the genre... after I unlock and beat The Siege of Lothlorien, of course. I don't currently have a favorite race/class combo -- I'm still having too much fun bouncing around from combo to combo and figuring out how to make them all work.
And the "10-minute" dungeon crawl? Blatant lies. I have yet to make a successful run in less than 20 minutes.
Current Wiki Project
February 2011: Right now I'm trying to finish writing the Challenge Mode strategies for all 18 classes, as I've noticed that many of the class pages are missing strategy details for one or more of the side dungeons.