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The Golem is a foe that will flummox spellcasters who rely heavily on the BURNDAYRAZ glyph due to its high magic resistance. Glyphs that target monsters, such as WEYTWUT and IMAWAL will also have a high chance of failure, while APHEELSIK has reduced effectiveness. However, the Golem is otherwise a mediocre foe and can be easily defeated by physical means.
The PISORF glyph completely ignores magic resistance, and will allow spellcaster-type characters to easily defeat them (provided there's a wall to crush them against). Any glyphs that help the player instead of hurting the monster will also be unaffected by this magic resistance. The HALPMEH glyph in particular is a good general-purpose glyph that will make killing golems easy.
The Golem boss, the Iron Man, has a whopping 75% magic resistance, but otherwise pertains all the same weaknesses as a regular Golem and is one of the easiest bosses to dispatch with swift and efficient melee attacks.