Reduced health and Corrosive makes this monster a very good target for caster approach. It is highly advisable to avoid taking damage from Acid Blob because of his Corrosive debuff. Because you want to avoid physical attacks against this monster, BLUDTUPOWA is particularly useful against it. If you have GETINDARE, precast it before the fight to have First Strike, so you can cast spells and finish Acid Blob without taking any Corrosion from him.
Like every other monster with Corrosive, Acid Blob leaves corrosive puddles instead of blood pools after his death, giving you 1 stack of Corrosion every time you step on them. Use WEYTWUT, WONAFYT or PISORF to move the enemy before killing it. Another option is to carve an alternate path with ENDISWAL or cast BLUDTUPOWA to reveal tile behind that pool so you can jump over it.
To cure corrosion: